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| Pascale Quintino,Marisa; Simões,Manuel de Jesus; Uchiyama Nakamura,Mary; Martins Oliveira-Filho,Ricardo; Espiridião,Silvia; Kulay Júnior,Luiz. |
| Although being used for years in the treatment of tuberculosis, no data are available in the literature on the safety of pyrazinamide during pregnancy. Accordingly, we aimed to make a first approach to this problem by evaluating the effects of this drug administered during the entire pregnancy of albino rats. Fourty female, EPM-1 Wistar albino rats of about 250 g b.w. were used. Upon conception (day zero of pregnancy) the animals were randomly divided in 4 groups of 10 rats each and labeled as follows. Controls (C), animals treated with the drug vehicle (destilled water); experimental groups (E1, E2 and E3), animals treated with 35, 105 or 315 mg/kg b.w. pyrazinamide by gavage (oral route) once daily up to the term (20th day of pregnancy). Drug or vehicle... |
| Tipo: Journal article |
Palavras-chave: Pyrazinamide; Toxicology; Rat; Pregnancy. |
| Ano: 2003 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000400007 |
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| Coelho Teixeira,Álvaro Aguiar; Simões,Manuel de Jesus; Wanderley Teixeira,Valéria; Soares Júnior,José Maria. |
| In this paper we evaluated the morphologic and quantitative aspects of the implantations sites in uteruses of female pinealectomized and/or submitted to the constant illumination rats. The experimental groups were: I - normal female rats maintained in a clear/dark cycle of 12/12 hours, for two months, mated and euthanasiated in the 6th day of pregnancy (control); II - female sham-pinealectomized rats maintained in a clear/dark cycle of 12/12 hours, for two months, mated and euthanasiated in the 6th day of pregnancy (control); III - female pinealectomized rats, maintained in a clear/dark cycle of 12/12 hours, for two months, mated and euthanasiated in the 6th day of pregnancy; IV - normal female rats maintained in constant illumination for two months, mated... |
| Tipo: Journal article |
Palavras-chave: Pinealectomy; Constant illumination; Implantation; Blastocyst. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000300003 |
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| Venneri Mathias,Cícero; Simões,Manuel de Jesus; Mahmed Amed,Abes; Martins Oliveira-Filho,Ricardo; Venneri Mathias,Camila Fernandes; dos Santos Simões,Ricardo; Kulay Júnior,Luiz. |
| There are few long-term data on which to base decisions of drug management of HIV infection in pregnancy. The determination of safe medications must take into consideration the need for certain drugs and the possibility of inadvertent fetal exposure because of unplanned pregnancies. The aim of this study was to evaluate the effects of foscarnet on the entire period of rat pregnancy. Female pregnant rats were randomly assigned to four treatment groups (n = 10): one control (C) treated with the drug vehicle (bidestilled water) and three experimental groups (E1, E2 and E3) treated with 180, 360 or 720 mg/Kg of foscarnet, respectively. Rats were treated by gavage once daily. The treatment period extended from the first until the 20th day of pregnancy. Body... |
| Tipo: Journal article |
Palavras-chave: Antiretroviral drugs; Foscarnet; Pregnancy; Rat. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200008 |
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